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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
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Conduction System of the Heart

Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
Conduction System of the Heart01:20

Conduction System of the Heart

The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
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Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
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Cardiomyopathy V: Interprofessional Care

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A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
07:49

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

Published on: July 21, 2023

Hisian pacing restores cardiac function.

Gaojun Wu1, Yongxin Cai, Weijian Huang

  • 1Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China.

Journal of Electrocardiology
|June 19, 2013
PubMed
Summary
This summary is machine-generated.

His-bundle pacing (HBP) offers a promising alternative for heart failure patients with complete left bundle branch block (CLBBB) when standard biventricular pacing is not feasible. This innovative approach rapidly improved a patient's symptoms and cardiac function.

Keywords:
Cardiac resynchronization therapyDilated cardiomyopathyHeart failureHis-bundle pacingLeft bundle branch block

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Dilated cardiomyopathy and complete left bundle branch block (CLBBB) often necessitate cardiac resynchronization therapy (CRT).
  • Standard CRT involves biventricular pacing, which can be challenging to implement in some patients.

Observation:

  • A 57-year-old male patient with dilated cardiomyopathy (NYHA class III) and CLBBB was unable to have a left-ventricular lead placed for CRT.
  • The patient subsequently received His-bundle pacing (HBP) as an alternative pacing strategy.

Findings:

  • Following HBP implantation, the patient experienced rapid symptom resolution over a 10-month follow-up period.
  • Significant improvements were observed in QRS duration, left ventricular dimensions, and left ventricular ejection fraction, indicating successful cardiac resynchronization.
  • His-bundle pacing effectively normalized cardiac electrical activity and improved heart function.

Implications:

  • His-bundle pacing presents a viable and potentially superior alternative to biventricular pacing for heart failure patients with CLBBB.
  • HBP may be particularly advantageous in cases where conventional CRT lead placement is not feasible.
  • This approach broadens therapeutic options for managing heart failure and improving patient outcomes.