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Clinical analysis of Enterobacter bacteremia in pediatric patients: a 10-year study

Hui-Lan Chen1, Jen-Her Lu1, Hsin-Hui Wang1

  • 1Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|June 19, 2013
PubMed

Insights

Enterobacter bacteremia is a significant nosocomial infection in premature neonates. Underlying diseases and leukocytosis are key factors influencing mortality in these pediatric patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Hospital-Acquired Infections
  • Bacteriology

Background:

  • Enterobacter species are increasingly recognized as significant pathogens causing nosocomial bacteremia.
  • Pediatric patients, particularly neonates, are vulnerable to these infections.

Purpose of the Study:

  • To investigate the clinical characteristics of Enterobacter bacteremia in pediatric patients.
  • To identify risk factors and outcomes associated with Enterobacter bacteremia in this population.

Main Methods:

  • Retrospective review of medical records of pediatric patients (<18 years) with Enterobacter bacteremia.
  • Data collected from January 2001 to June 2011 at Taipei Veterans General Hospital.

Main Results:

  • Enterobacter bacteremia accounted for 11.3% of all bacteremia episodes (96/853), predominantly as nosocomial infections (98.8%).
  • Neonates (74.7%) and premature infants (61.5%) were the most affected groups.
  • Respiratory tract infections were the most common source (53.0%); overall case fatality rate was 18.1%, highest in premature infants, linked to leukocytosis and comorbidities.

Conclusions:

  • Enterobacter species represent a critical pathogen in nosocomial bacteremia among premature neonates.
  • The number of underlying diseases is a significant determinant of prognosis in pediatric Enterobacter bacteremia.
Abstract

Keywords:
BacteremiaEnterobacterNeonates

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