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Updated: May 10, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
An experimental study to determine the optimal access route for renal artery interventions
K M Coghlan1, L T Breen, Z Martin
1Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
Summary
Renal artery access is challenging for angles <30°. A superior approach is recommended for angles between 33-38°, especially with stiff guide wires, to ensure stable guide wire placement.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Medical Device Engineering
Background:
- Standard endovascular renal artery treatment uses common femoral artery access.
- Anatomical variations, specifically renal artery take-off angles <50°, present technical challenges for femoral access.
Purpose of the Study:
- To determine the critical renal artery take-off angle necessitating a superior approach.
- To empirically assess guide catheter and guide wire performance in challenging renal artery anatomy.
Main Methods:
- Constructed an experimental model of the aorta and renal arteries from patient CT angiography data.
- Evaluated force/displacement responses of various guide catheter and guide wire combinations.
Main Results:
- Renal artery take-off angles <30° significantly reduced stable guide wire placement probability (p ≤ .0001).
- Minimizing stiffness mismatch between guide catheter and guide wire improved access success.
Conclusions:
- A superior approach is advised for renal artery take-off angles of 33-38°.
- A stiff guide wire platform is recommended for procedures in this angle range.
- An equation was developed to predict renal artery access difficulty relative to 90° anatomy.
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