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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Comparative phenotypic characterization of human cord blood monocytes and placental macrophages at term

S A Selkov1, A V Selutin, O M Pavlova

  • 1D.O. Ott Research Institute for Obstetrics and Gynecology, St. Petersburg, Russia.

Placenta
|June 19, 2013
PubMed

The expression of surface molecules in cord blood monocytes and placental macrophages was studied using flow cytometry. When compared with monocytes, macrophages presented a decrease in HLA-DR and LAP/TGF-β1 levels and increased expression of alternative activation markers, especially CD206. No difference in the production of the apoptotic factors TRAIL and TWEAK was observed, whereas the levels of cytokine receptors in monocytes were significantly higher than in macrophages. Most remarkable was the difference in the expression of IL-17 and TNFα receptors. A strong correlation between VEGF and TNFα receptors was revealed in both cell populations. The results obtained in this study provide antigenic phenotypes for two related cell populations and outline the feasible functional alterations during tissue macrophage differentiation.

Keywords:
Apoptotic factorsCord blood monocytesCytokine receptorsDifferentiation markersPlacental macrophages

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