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Updated: May 10, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
[Recurrent pericarditis related to primary pericardial malignant mesothelioma]
P Smets1, G Guettrot-Imbert, M Hermet
1Service de médecine interne, centre hospitalier universitaire Gabriel Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand cedex 1, France.
Introduction:
Most of recurrent pericarditis are idiopathic and only 15 to 20% have a specific diagnosis. Primary pericardial mesothelioma is a rare cause of recurrent pericarditis. Diagnosis can be challenging and antedates patient's death in only 10 to 20% of cases. Histology of mesothelioma and immunohistochemistry are mandatory for the diagnosis. Median of survival before using pemetrexed was about 6 months after diagnosis.
Case Report:
We report the history of a 64-year-old woman for which repeated biopsy for recurrent pericarditis was necessary to diagnose a primary pericardial mesothelioma. The first biopsy had only found mesothelial hyperplasia.
Conclusion:
This case report highlights the necessity of repeat pericardial biopsy in the case of adverse outcome.
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