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[Recurrent pericarditis related to primary pericardial malignant mesothelioma]

P Smets1, G Guettrot-Imbert, M Hermet

  • 1Service de médecine interne, centre hospitalier universitaire Gabriel Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand cedex 1, France.

La Revue De Medecine Interne
|June 19, 2013
PubMed
Abstract

Insights

Recurrent pericarditis diagnosis can be challenging. Repeat pericardial biopsy is crucial for identifying rare causes like primary pericardial mesothelioma, especially with poor outcomes.

Area of Science:

  • Cardiology
  • Oncology
  • Pathology

Background:

  • Recurrent pericarditis is often idiopathic, with specific diagnoses in only 15-20% of cases.
  • Primary pericardial mesothelioma is a rare but fatal cause of recurrent pericarditis.
  • Diagnosis is challenging, with histology and immunohistochemistry being essential.

Observation:

  • A 64-year-old woman presented with recurrent pericarditis.
  • Initial pericardial biopsy revealed mesothelial hyperplasia, not mesothelioma.
  • Repeated biopsy was required for definitive diagnosis.

Findings:

  • The case highlights the diagnostic difficulty of primary pericardial mesothelioma.
  • Histological confirmation via repeat biopsy was critical.
  • Early diagnosis is vital, as median survival was approximately 6 months pre-pemetrexed therapy.

Implications:

  • This case underscores the importance of repeat pericardial biopsies in refractory or severe cases.
  • It emphasizes the need for thorough pathological examination in diagnosing rare pericardial conditions.
  • Improved diagnostic strategies are needed for primary pericardial mesothelioma.
Keywords:
Hyperplasie mésothélialeMalignant mesotheliomaMesothelial hyperplasiaMésothéliome malinPéricardite récidivanteRecurrent pericarditis

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