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Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
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Cognitive Development During Adolescence

During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the recognition that people have...
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Revisionist Views of Adolescent and Adult Cognition

A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are themselves.

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Related Experiment Video

Updated: May 10, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Developmental changes in hippocampal shape among preadolescent children.

Muqing Lin1, Peter T Fwu, Claudia Buss

  • 1Tu & Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, USA.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|June 19, 2013
PubMed
Summary

Hippocampal shape analysis in children aged 6-10 reveals that the head segment expands with age, particularly in girls. This method detects changes missed by volume analysis, aiding future developmental and psychopathology research.

Keywords:
ADAlzheimer's diseaseCTDemons algorithmFDRHippocampal shape analysisICBMIR-SPGRInternational Consortium for Brain MappingLDDMMLarge Deformation Diffeomorphic Metric MappingMNIMRIMontreal Neurological InstituteNon-rigid registrationPETPositron emission tomographyRDDRDMROIRPMRadial distance mappingRobust point matching algorithmTETFETITRcomputed tomographyecho timefalse discovery rateinversion timeinversion-recovery spoiled gradient recalled acquisitionmagnetic resonance imagingradial distance differenceradial distance mappingregion of interestrepetition timerobust point matchingturbo field echo

More Related Videos

Three-Dimensional Shape Modeling and Analysis of Brain Structures
05:33

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

Related Experiment Videos

Last Updated: May 10, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Three-Dimensional Shape Modeling and Analysis of Brain Structures
05:33

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • The hippocampus undergoes significant development prenatally and in early infancy.
  • Limited research exists on the normal hippocampal developmental trajectory throughout childhood.

Purpose of the Study:

  • To investigate the normal developmental trajectory of the hippocampus in preadolescent children using advanced shape analysis techniques.
  • To compare the sensitivity of shape analysis versus volumetric analysis in detecting age-related hippocampal changes.

Main Methods:

  • Applied three shape analysis methods (radial distance mapping, surface-based template registration with Robust Point Matching (RPM), and volume-based template registration using the Demons algorithm) to segmented hippocampi from 103 typically developing children (6-10 years old).
  • Analyzed hippocampal head, body, and tail sub-regions.
  • Stratified analyses by sex.

Main Results:

  • All three shape analysis methods indicated bilateral expansion of the hippocampal head segment in older children compared to younger children.
  • Age-associated anatomical changes were similar in boys and girls, with the strongest association observed in girls.
  • Volumetric analysis of total and sub-regional hippocampal volumes did not reveal significant age-associations.

Conclusions:

  • Hippocampal shape analysis is more sensitive than volumetric analysis for detecting subtle, sub-regional developmental changes in children.
  • The presented shape analysis methods can be utilized for future studies on normal hippocampal development and early detection of deviations linked to psychopathological disorders.