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Pubertal growth in chronic renal failure
F Schaefer1, C Seidel, A Binding
1Division of Paediatric Nephrology, University Children's Hospital, Heidelberg, Federal Republic of Germany.
Pediatric Research
|July 1, 1990
Summary
Children with end-stage renal failure before puberty experience significantly reduced pubertal growth. This irreversible loss of growth potential impacts height gain, even after kidney transplantation.
Area of Science:
- Pediatric Nephrology
- Growth and Development
- Endocrinology
Background:
- End-stage renal failure (ESRF) in children can impact growth.
- Pubertal growth spurt is a critical period for achieving final height.
Purpose of the Study:
- To evaluate pubertal growth patterns in children with ESRF.
- To compare growth in ESRF patients with healthy controls.
Main Methods:
- Analysis of growth records from 15 boys and 14 girls with ESRF.
- Kernel estimation for height data smoothing.
- Comparison of mean values for age, height, and height velocity during puberty.
Main Results:
- Pubertal growth spurt onset delayed by 2.5 years in both sexes.
- Reduced duration and intensity of pubertal growth spurt.
- Mean pubertal height gain was 58% (boys) and 48% (girls) of controls.
- Height declined significantly below normal during the pubertal spurt.
- Renal transplantation did not consistently improve pubertal growth.
Conclusions:
- Children with ESRF before or during puberty irreversibly lose growth potential.
- Growth deficits are significant and persist despite transplantation.
- Early intervention and management are crucial for optimizing growth in pediatric ESRF.