Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zinner Syndrome: An Incidental Finding.

Cureus·2026
Same author

Recurrent Multifocal Urothelial Carcinoma: A Case Report.

Cureus·2026
Same author

Systemic Treatment of Metastatic Sertoli Cell Tumor.

Cureus·2026
Same author

Sex based differences in time processing were found in newly developed tasks.

Psychological research·2026
Same author

NMR and SPR Fragment-Based Screening Can Produce Novel High Affinity Small Molecule Hits against Structured RNAs.

ACS chemical biology·2025
Same author

Prior restraint stress counteracts memory deficits associated with adolescent alcohol exposure by targeting both the hippocampal endocannabinoid and glutamatergic systems.

Drug and alcohol dependence·2025

Related Experiment Video

Updated: May 10, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Spatial recognition memory in a virtual reality task is altered in refractory temporal lobe epilepsy.

Katiuska Rosas1, Isabel Parrón, Pedro Serrano

  • 1Service of Neurology, Torrecardenas Hospital, Almeria, Spain.

Epilepsy & Behavior : E&B
|June 19, 2013
PubMed
Summary

Temporal lobe epilepsy patients show normal spatial learning but impaired spatial recognition. Virtual reality tasks reveal this cognitive difference, highlighting hippocampal involvement in spatial representation.

More Related Videos

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
08:59

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

Related Experiment Videos

Last Updated: May 10, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
08:59

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Cognitive Psychology

Background:

  • Temporal lobe epilepsy (TLE) frequently resists medical treatment, leading to prolonged seizure periods.
  • Patients with TLE may experience cognitive alterations during the medically refractory phase.
  • Virtual reality (VR) offers novel methods for assessing cognition in clinical populations.

Purpose of the Study:

  • To assess spatial learning and spatial recognition in patients with pharmacoresistant TLE using VR.
  • To investigate the utility of VR-based neuropsychological tasks for detecting cognitive deficits in TLE.

Main Methods:

  • Coupled spatial learning and recognition tasks within a VR environment.
  • Tested 8 subjects with pharmacoresistant TLE and 8 healthy controls.
  • Collected data on reaction time and error rates for each task.

Main Results:

  • No significant differences were observed between groups in spatial learning.
  • Patients with TLE demonstrated poorer spatial recognition compared to controls.
  • Control subjects exhibited shorter reaction times and fewer errors in recognition tasks.

Conclusions:

  • Spatial recognition tasks are sensitive to hippocampal disturbances associated with TLE.
  • Findings support the hippocampus's critical role in allothetic environmental representation.
  • VR-based neuropsychological assessments show promise for evaluating TLE-related cognitive changes.