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Updated: May 10, 2026
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
[MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas]
Orsolya Kiss1, Anna-Mária Tőkés, Sándor Spisák
1Semmelweis Egyetem, Általános Orvostudományi Kar, II. Patológiai Intézet, Budapest. kj@korb2.sote.hu
Introduction:
Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis.
Aim:
The aim of the authors was to compare the miRNA-expression profile of breast- and salivary gland-derived cases.
Method:
The miRNA-profiles of two salivary gland derived and two breast-derived adenoid cystic carcinoma tissues as well as one normal breast and one salivary gland tissues were analysed using the Affymetrix® Gene Chip.
Results:
The expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma. In addition, the miR-24 was decreased in salivary gland-derived but overexpressed in breast-derived adenoid cystic carcinomas. The miR-181a-2* was only detected in salivary gland-derived adenoid cystic carcinomas.
Conclusions:
Through post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas.
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