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Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Cell Signaling in Plants01:25

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
Key Elements for Plant Nutrition02:35

Key Elements for Plant Nutrition

Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the atmosphere, the...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...

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Updated: May 10, 2026

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
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Published on: August 8, 2025

Quorum sensing and phytochemicals.

Filomena Nazzaro1, Florinda Fratianni, Raffaele Coppola

  • 1Institute of Food Science, ISA-CNR, Via Roma 64, Avellino 83100, Italy. mena@isa.cnr.it.

International Journal of Molecular Sciences
|June 19, 2013
PubMed
Summary

Natural compounds can block bacterial quorum sensing (QS) and disrupt biofilms, offering a new way to fight infections. These plant-derived QS inhibitors show promise for treating bacterial diseases and improving food safety.

Area of Science:

  • Microbiology
  • Biochemistry
  • Pharmacology

Background:

  • Infectious diseases are frequently caused by bacteria that form biofilms.
  • Biofilms are protected communities of bacteria that are difficult to eradicate.
  • Bacterial quorum sensing (QS) is a key process for biofilm formation and virulence.

Purpose of the Study:

  • To review natural quorum sensing inhibitors.
  • To highlight their potential in combating bacterial infections.
  • To discuss their role in enhancing food supply safety.

Main Methods:

  • Literature review of natural products with QS inhibitory activity.
  • Analysis of plant-derived compounds targeting bacterial QS pathways.
  • Evaluation of biofilm disruption capabilities.

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Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
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Synthesis and Assay of Vibrio Quorum Sensing Inhibitors

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Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
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Synthesis and Assay of Vibrio Quorum Sensing Inhibitors

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Main Results:

  • Numerous plant-derived natural products exhibit significant QS inhibitory activity.
  • These compounds effectively disrupt bacterial biofilms.
  • Natural QS inhibitors present a viable alternative to conventional antibiotics.

Conclusions:

  • Natural QS inhibitors offer a promising strategy for managing infectious diseases.
  • Targeting QS pathways can overcome antibiotic resistance.
  • These compounds contribute to safer food production by controlling bacterial contamination.