Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway.

Toxicology letters·2013
Same author

A prospective, randomized, open-label study comparing the efficacy and safety of preprandial and prandial insulin in combination with acarbose in elderly, insulin-requiring patients with type 2 diabetes mellitus.

Diabetes technology & therapeutics·2013
Same author

Synthesis of the C-18-C-34 fragment of amphidinolides C, C2, and C3.

Organic letters·2013
Same author

Synthesis of the C-1-C-17 fragment of amphidinolides C, C2, C3, and F.

Organic letters·2013
Same author

77Se solid-state NMR of As2Se3, As4Se4 and As4Se3 crystals: a combined experimental and computational study.

Physical chemistry chemical physics : PCCP·2013
Same author

Nanocellulose electroconductive composites.

Nanoscale·2013
Same journal

[Gout of the manubriosternal joints: A case report].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026
Same journal

[Bone marrow infiltration of large B-cell lymphoma with clinical manifestations similar to systemic lupus erythematosus: A case report].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026
Same journal

[A new method for extracting adult mouse cardiac fibroblasts more efficiently and stably].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026
Same journal

[Clinical and imaging characteristics and etiology of 544 cases with chronic sialadenitis].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026
Same journal

[Dynamic stretching promotes osteogenic differentiation of human bone marrow mesenchymal stem cells in three-dimensional culture].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026
Same journal

[Molecular characteristics for poor prognosis related renal cell carcinoma with lymph metastases].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

[Stem cells and diabetic nephropathy].

Guang Yang1, Qing-li Cheng

  • 1Department of Geriatric Nephrology, Chinese PLA General Hospital, Beijing, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|June 19, 2013
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for treating diabetic nephropathy (DN), a common diabetes complication. This review explores stem cells

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Related Experiment Videos

Last Updated: May 10, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Area of Science:

  • Regenerative Medicine
  • Nephrology
  • Endocrinology

Background:

  • Diabetic nephropathy (DN) is a leading microvascular complication of diabetes mellitus.
  • Current treatments targeting the renin-angiotensin system and risk factors like hypertension and hyperglycemia offer limited efficacy.
  • The limitations of existing therapies highlight the need for novel treatment strategies.

Purpose of the Study:

  • To review the therapeutic potential of stem cells for treating diabetic nephropathy (DN).
  • To discuss the impact of the diabetic milieu on stem cell function.
  • To explore the immunomodulatory and regenerative benefits of stem cells in DN treatment.

Main Methods:

  • Literature review of preclinical and clinical studies on stem cell therapy in DN.
  • Analysis of stem cell properties including self-renewal, differentiation, and immunomodulation.
  • Examination of the effects of the diabetic environment on stem cell efficacy.

Main Results:

  • Stem cells possess self-renewal, multi-lineage differentiation, and immunomodulatory capabilities.
  • The diabetic environment can negatively affect stem cell function and therapeutic potential.
  • Stem cell transplantation demonstrates potential benefits in preclinical models of DN.

Conclusions:

  • Stem cell therapy represents a promising novel strategy for managing diabetic nephropathy.
  • Further research is needed to optimize stem cell-based treatments for DN.
  • Understanding stem cell-biomaterial interactions is crucial for therapeutic development.