Related Experiment Video
Updated: May 10, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Granulomatous reaction within the thyroid metastases of a renal cell carcinoma
Francesco A D'Angelo1, Paolo Magistri, Laura Antolino
11Department of General Surgery, St Andrea University Hospital, Rome, Italy.
Abstract:
Metastases of non-thyroid malignancies to the thyroid gland have been reported in 1.4% to 3% of patients undergoing thyroid surgery for thyroid malignancy. We report a case of thyroid metastases from renal cell carcinoma in a 57-year-old man, who underwent a left nephrectomy 11 years earlier for a renal cell carcinoma. The histological examination demonstrated a CD-10 positive and thyroglobulin and thyroid transcription factor-1 negative tissue, with numerous noncaseating gigantocellular granulomas. These findings are interesting for the possible role of the immune response in metastatic localizations.
Related Concept Videos
Graves Disease II: Pathophysiology
Graves' Disease I: Introduction
Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology
Hypersensitivity Reactions: Immune-Complex Reactions
Hypersensitivity Reactions: Cytolytic Reactions
