Related Experiment Video
Updated: May 10, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
Published on: December 3, 2017
[Infected knee prostheses. Part 2: chronic late infections]
P Herrmann1, P Thoele, V Heppert
1Abteilung Unfall-, Wirbelsäulen- und Gelenkchirurgie, Asklepios-Südpfalzklinik Kandel, Luitpoldstr. 14, 76870 Kandel, Germany. pe.herrmann@asklepios.com
Objective:
Treatment of late and chronic infections, which require the replacement of all the infected implant material.
Indications:
All infections lasting more than 4 weeks that have been proven to be bacterial and/or obvious signs of infection.
Contraindications:
Unsuitable for anesthesia, high acute infection with sepsis and risk for bacteremia with danger to life, large soft tissue damage where plastic surgery coverage is not possible.
Surgical Technique:
Arthrotomy, synovectomy, removal of all foreign bodies including all residue of polymethylmethacrylate (PMMA), jet lavage, spacer, drainage, wound closure or temporary closure using vacuum sealing.
Postoperative Management:
Bed rest with a leg brace and drainage until daily drainage volume is <50 ml, then mobilization with no weight-bearing in an orthesis, 4 weeks systemic antibiotics, after 2 weeks without antibiotics aspiration of the joint, when no bacteria are found reimplantation of a revision TKA (total knee arthroplasty) and with plastic surgery for coverage (gastrognemius flap) if necessary, when bacteria are found again revision with exchange of the spacer.
Results:
In the literature, the success rate for both the one-stage or the two-stage procedure is about 80-95%. In our very nonhomogeneous collective the overall rate of success is about 81%.
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