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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Published on: June 13, 2014

[Personalized neurooncology].

M Platten1, J P Steinbach, W Wick

  • 1Abteilung Neuroonkologie, Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen, Universitätsklinikum Heidelberg, INF 400, 69120, Heidelberg, Deutschland. michael.platten@med.uni-heidelberg.de

Der Nervenarzt
|June 19, 2013
PubMed
Summary
This summary is machine-generated.

Personalized neuro-oncology is evolving, shifting treatment decisions for brain tumors from histology to molecular markers. Molecular analysis, like MGMT promoter hypermethylation, now guides personalized therapy, improving patient outcomes.

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Area of Science:

  • Neuro-oncology
  • Molecular diagnostics
  • Genomics

Context:

  • Brain tumor treatment is shifting from traditional histology-based methods to molecular profiling.
  • Randomized trials increasingly support personalized, molecular-guided treatment decisions.
  • Molecular markers are becoming crucial predictors of therapy response.

Purpose:

  • To illustrate current developments in personalized neuro-oncology.
  • To critically review the impact of molecular diagnostics on clinical decision-making.
  • To highlight the integration of molecular markers into routine brain tumor treatment.

Summary:

  • Intrinsic brain tumor treatment is transitioning towards personalized approaches driven by molecular markers.
  • The German NOA-08 trial demonstrated temozolomide chemotherapy efficacy in malignant gliomas with MGMT promoter hypermethylation.
  • Molecular analysis of tumor tissue is now clinically relevant for treatment decisions, not just prognosis.

Impact:

  • Molecular diagnostics are revolutionizing brain tumor treatment strategies.
  • Personalized medicine in neuro-oncology enhances treatment efficacy and patient selection.
  • Clinical decision-making for brain tumors is increasingly informed by molecular data.