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[Clinical experience with a hydrolyzed soy formula in infants with protracted enteritis and atopic eczema]
F Donzelli1, L Da Dalt, A Schiavon
1Dipartimento di Pediatria, Università di Padova, Italia.
Insights
This study found that Pregomin, a soy and beef hydrolysate formula, effectively improved growth and reduced symptoms in infants with enteritis and atopic eczema. It did not cause allergic sensitization to soy protein in infants not previously exposed.
Area of Science:
- Pediatric Gastroenterology
- Allergology
- Clinical Nutrition
Context:
- Infants with protracted enteritis and atopic eczema often face nutritional challenges and potential food allergies.
- Hydrolyzed protein formulas are used to manage these conditions, but their potential for causing sensitization requires evaluation.
Purpose:
- To assess the efficacy and safety of a lactose-free soy and beef hydrolysate formula (Pregomin) in infants with protracted enteritis and atopic eczema.
- To determine if Pregomin induces allergic sensitization to intact soy protein through oral provocation testing.
Summary:
- Pregomin administration led to catch-up growth and improved laboratory markers in infants with enteritis.
- Infants with atopic eczema showed clinical improvement and negative allergic tests after Pregomin treatment.
- Oral provocation tests with intact soy protein revealed sensitization only in infants with prior soy protein exposure, suggesting Pregomin is non-allergenic for naive infants.
Impact:
- Pregomin demonstrates efficacy in both gastroenterological and allergological aspects for affected infants.
- The formula appears safe and non-allergenic, particularly for infants without prior soy exposure.
- These findings support the use of Pregomin in managing specific pediatric gastrointestinal and allergic conditions.
Abstract:
A lactose-free soy and beef hydrolysate based formula ("Pregomin" Milupa) was studied in 12 infants affected with protracted enteritis and in 10 infants affected with atopic eczema. After 1 month of treatment with "Pregomin" an oral provocation test was performed using intact soy protein. The aim of this latter test was to evaluate if the hydrolysed soy formula could cause allergic sensitization to soy protein. We obtained the following results in the group of infants with enteritis: good catch-up growth, malnutrition laboratory test improvement, negative allergic tests, positive oral provocation test in only one infant who had been previously fed with intact soy protein. In the group with atopic eczema we found an improvement of the eczema, negative allergic tests, 3 out of 9 positive oral provocation tests (in infants previously fed with soy protein based formulas). Our data show that "Pregomin" formula was effective both from a gastroenterological point of view and from an allergological one. Furthermore we did not observe any positive oral provocation test with soy protein in infants who had never been exposed to this type of protein. The latter result seems to demonstrate that "Pregomin" formula does not possess any allergenic properties.