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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: May 10, 2026

Study of Experimental Organ Donation Models for Lung Transplantation
08:56

Study of Experimental Organ Donation Models for Lung Transplantation

Published on: March 15, 2024

Thoracic organ transplantation: laboratory methods.

Jignesh K Patel1, Jon A Kobashigawa

  • 1Cedars-Sinai Heart Institute, Los Angeles, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|June 19, 2013
PubMed
Summary

Monitoring thoracic organ transplant recipients is crucial for detecting rejection. Current antibody and cellular assays improve management, with future techniques promising more refined allograft monitoring.

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Clinical Diagnostics

Background:

  • Effective immunosuppression has advanced thoracic organ transplantation, yet early post-transplant rejection remains a significant risk.
  • Routine monitoring for acute antibody-mediated and cellular-mediated rejection is essential for patient management.

Purpose of the Study:

  • To review current antibody and cellular monitoring techniques in thoracic organ transplantation.
  • To highlight the role of these techniques in managing transplant recipients and discuss future directions.

Main Methods:

  • Multiplexed, microbead assays for sensitive detection and identification of HLA and non-HLA specific antibodies.
  • Gene expression profiling for noninvasive monitoring of cellular immune responses in heart transplant recipients.

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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

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Study of Experimental Organ Donation Models for Lung Transplantation
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  • T cell immune monitoring for tailoring immunosuppression in heart and lung transplant recipients.

    • Main Results:

    • Multiplexed assays facilitate assessment of donor-specific antibodies, virtual crossmatches, and post-transplant antibody monitoring.
    • Gene expression profiling provides predictive values for acute cellular rejection in heart transplants.
    • T cell monitoring enables personalized immunosuppression strategies, reducing infection risk.

    Conclusions:

    • Current antibody and cellular laboratory techniques significantly enhance the management of thoracic organ transplant recipients.
    • Future advancements in understanding microchimerism and graft tolerance may lead to more refined allograft monitoring strategies.