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Long-term risk of recurrent vascular events after young stroke: The FUTURE study

Loes C A Rutten-Jacobs1, Noortje A M Maaijwee, Renate M Arntz

  • 1Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Center, Nijmegen.

Annals of Neurology
|June 19, 2013
PubMed

Insights

Young stroke survivors face a significant, lifelong risk of recurrent vascular events. This includes stroke, heart attack, and arterial procedures, underscoring the need for ongoing management.

Area of Science:

  • Neurology
  • Cardiology
  • Vascular Medicine

Background:

  • Long-term data on recurrent vascular events following strokes in young adults are scarce.
  • Understanding these risks is crucial for effective long-term patient management.

Purpose of the Study:

  • To investigate the long-term risk of recurrent vascular events in patients who experienced a first-ever stroke at a young age.
  • To identify factors associated with recurrent vascular events after young stroke.

Main Methods:

  • Prospective study of 724 patients aged 18-50 with a first-ever transient ischemic attack (TIA), ischemic stroke, or intracerebral hemorrhage (ICH).
  • Follow-up averaged 9.1 years, assessing recurrent stroke, myocardial infarction, arterial revascularization, or composite events.
  • Analysis included TOAST subtypes, age, sex, and decennium of inclusion.

Main Results:

  • 19.6% of patients experienced at least one recurrent vascular event.
  • Cumulative 20-year stroke risk was 17.3% after TIA and 19.4% after ischemic stroke.
  • Atherothrombotic, cardioembolic, and lacunar stroke subtypes were associated with increased recurrent stroke risk.

Conclusions:

  • Young stroke patients face a substantial and prolonged risk of recurrent vascular events.
  • The underlying causes of young stroke contribute to lifelong vascular disease risk.
  • Continued monitoring and management are essential for this patient population.
Abstract

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