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Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons.

Daniela Hartl1, Stephan Klatt, Manfred Roch

  • 1Institute for Medical Genetics and Human Genetics, Charité - University Medicine, Berlin, Germany. daniela.hartl@charite.de

Plos One
|June 19, 2013
PubMed
Summary

Soluble alpha-amyloid precursor protein (sAPPalpha) may protect neurons in Alzheimer disease (AD) by regulating CDK5 and inducing the chaperone ORP150. The receptor SORLA is crucial for mediating these neuroprotective effects.

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