Stem cell therapy in stroke: a review literature

Area of Science:

• Neuroscience
• Regenerative Medicine
• Clinical Neurology

Background:

• Stroke is a leading cause of death and long-term disability globally, particularly in developed nations.
• Current treatments like thrombolytic agents are effective in the acute phase but often leave patients with enduring neurological deficits.
• There is a critical need for novel therapeutic strategies to mitigate post-stroke neurological impairments.

Purpose of the Study:

• To review current stem cell (SC) therapy approaches for stroke patients.
• To discuss the efficacy of different SC types and administration routes in stroke treatment.
• To highlight the potential of SC therapy as a disease-modifying intervention for stroke recovery.

Main Methods:

• Literature review of studies on stem cell therapy in stroke.
• Analysis of different stem cell types used in preclinical and clinical stroke research.
• Evaluation of various routes of administration for stem cell delivery in stroke models and patients.

Main Results:

• Stem cell therapy demonstrates potential in reducing neurological deficits following stroke.
• Different stem cell types (e.g., mesenchymal stem cells, neural stem cells) show varying degrees of efficacy.
• Administration routes, including intravenous, intracerebral, and intrathecal, impact therapeutic outcomes.

Conclusions:

• Stem cell therapy represents a viable alternative for managing persistent deficits after stroke.
• Further research is warranted to optimize cell types and delivery methods for maximal therapeutic benefit.
• Stem cell therapy holds promise for improving functional recovery and quality of life in stroke survivors.