Restless legs syndrome in Iranian multiple sclerosis patients: a case-control study

Area of Science:

• Neurology
• Movement Disorders

Background:

• Restless Legs Syndrome (RLS) is a common neurological movement disorder.
• Both genetic and lifestyle factors contribute to RLS occurrence.
• Multiple Sclerosis (MS) is a chronic neurological condition affecting the central nervous system.

Purpose of the Study:

• To determine the prevalence of Restless Legs Syndrome (RLS) in Iranian patients with Multiple Sclerosis (MS).
• To identify potential risk factors associated with RLS in MS patients.

Main Methods:

• A cross-sectional study involving 126 MS patients and 126 age- and sex-matched healthy controls.
• Participants were assessed for RLS symptoms using standardized questionnaires.
• Data collected included demographics, MS characteristics, family history of RLS, anemia history, and medication use.

Main Results:

• RLS prevalence was significantly higher in MS patients (65.1%) compared to controls (12.7%).
• Mean age of MS patients with RLS was higher than those without RLS.
• Higher Expanded Disability Status Scale (EDSS) scores correlated with increased RLS symptoms in MS patients.

Conclusions:

• RLS should be routinely considered in the neurological assessment of MS patients.
• The findings highlight a significant association between MS and RLS, suggesting further investigation into underlying mechanisms.