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Is anti-cyclic citrullinated Peptide antibody a good value biomarker for Alzheimer disease?
Rokhsareh Meamar1, Gholamreza Askari, Majid Ghasemi
1Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran.
Background:
Alzheimer's disease (AD) is one of the most important neurodegenerative disorder. Anti-cyclic citrullinated peptide (anti-CCP) may all be involved in the development of vascular disease such as AD. The aim of this study is detection of seropositivity for anti-CCP antibody in AD patients.
Methods:
In our study, 30 patients with AD and 29 healthy controls (age and-sex matched) were recruited. Homocysteine and anti-CCP was measured by spectrophotometrically and immunoassay.
Results:
Mean ± SE anti-CCP was higher significantly between AD (13.6 ± 3) and healthy subjects (4.8 ± 0.2) (P = 0.006). In the patients, anti-CCP serum level was in high range (32.1%) of abnormal levels, but there was no significant difference in serum homocysteine in AD patients compared with controls. There is no correlation between anti-CCP and homocysteine levels in AD patients (P = 0.75), but between age and anti-CCP level observed a significantly correlation (P = 0.04).
Conclusions:
It needs more studies to clarify confirmation the role of anti-CCP antibody production in AD patients.
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