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Olanzapine versus haloperidol: which can control stuttering better?
Vahid Shaygannejad1, Seyed Ahmadreza Khatoonabadi, Bijan Shafiei
1Department of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
International Journal of Preventive Medicine
|June 19, 2013
Summary
Olanzapine demonstrated a superior effect in managing stuttering symptoms compared to haloperidol. This study suggests olanzapine may be a preferred first-line treatment for stuttering, requiring careful patient monitoring.
Area of Science:
- Pharmacology
- Speech-Language Pathology
- Clinical Trials
Background:
- Stuttering, a complex speech disorder, presents significant challenges in management.
- Antipsychotic medications are sometimes explored for their potential to modulate speech patterns.
Purpose of the Study:
- To compare the efficacy of olanzapine and haloperidol in controlling stuttering.
- To evaluate the impact of these medications on stuttering severity.
Main Methods:
- A 12-week single-blind randomized clinical trial involving 93 patients.
- Patients received either olanzapine (5 mg/day) or haloperidol (2.5 mg/day).
- Speech pathologists assessed stuttering using Van Riper's questionnaire before and after treatment.
Main Results:
- Both groups showed reduced stuttering scores post-treatment.
- The olanzapine group exhibited a significantly greater reduction in stuttering scores (P = 0.000).
- Initial stuttering scores were comparable between the haloperidol and olanzapine groups (P > 0.05).
Conclusions:
- Olanzapine appears to be more effective than haloperidol in controlling stuttering.
- Olanzapine may be considered a potential first-choice medication for stuttering management.
- Careful follow-up is recommended when prescribing olanzapine for stuttering.
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