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Updated: May 10, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Infantile rhabdomyofibrosarcoma: A potentially underdiagnosed aggressive tumor

Narendra Chaudhary1, Tanuja Shet, Anupama Borker

  • 1Department of Child Health, Christian Medical College, Vellore, Tamil Nadu, India.

International Journal of Applied & Basic Medical Research
|June 19, 2013
PubMed

Insights

Infantile Rhabdomyofibrosarcoma (IRMFS) is a rare soft-tissue tumor. Differentiating IRMFS from infantile fibrosarcoma (IFS) is crucial for appropriate treatment and prognosis.

Area of Science:

  • Pediatric Oncology
  • Surgical Pathology
  • Soft Tissue Tumors

Background:

  • Infantile Rhabdomyofibrosarcoma (IRMFS) is a rare tumor mimicking infantile fibrosarcoma (IFS).
  • Distinguishing IRMFS from IFS is critical due to differing prognoses and treatment strategies.

Observation:

  • A case report of a 2-year, 6-month-old boy with a left axillary soft-tissue mass.
  • Initial histopathology suggested IFS, but subsequent immunohistochemistry confirmed IRMFS (desmin-positive).

Findings:

  • The patient received aggressive adjuvant chemotherapy following diagnosis.
  • Complete remission was achieved 6 months post-chemotherapy.

Implications:

  • Accurate differentiation of IRMFS from IFS is essential for effective treatment planning.
  • Early and correct diagnosis can prevent under-treatment of this aggressive tumor.

Keywords:
Immunohistochemistryinfantile fibrosarcomainfantile rhabdomyofibrosarcoma

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