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Updated: May 10, 2026

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Published on: January 8, 2020

Endoscopic orbital decompression for Graves' orbitopathy.

Priti Lal¹, Alok Thakar, Nikhil Tandon

¹Department of Otolaryngology and Head and Neck Surgery, Safdarjung Hospital and Vardhman Mahavir Medical College, Ansari Nagar, New Delhi, India.

Indian Journal of Endocrinology and Metabolism

|June 19, 2013

Summary

This summary is machine-generated.

Endonasal endoscopic orbital decompression effectively reduces proptosis in Graves orbitopathy. This minimally invasive technique improves vision and offers a safe treatment option for affected patients.

Keywords:

Endoscopic Graves disease orbital decompression proptosis visual loss

Related Experiment Videos

Last Updated: May 10, 2026

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

Published on: January 8, 2020

Area of Science:

Ophthalmology
Endocrinology
Otorhinolaryngology

Background:

Graves orbitopathy is an autoimmune condition causing inflammation and swelling behind the eye.
Proptosis, corneal exposure, and optic nerve compression are common complications requiring intervention.

Purpose of the Study:

To evaluate the efficacy and safety of endonasal endoscopic orbital decompression.
To assess outcomes in patients with Graves orbitopathy.

Main Methods:

24 orbits in 12 patients underwent endoscopic orbital decompression.
Surgical technique involved removing medial and inferior orbital walls and slitting periosteum.
Pre- and postoperative exophthalmometry and visual acuity were recorded.

Main Results:

Mean orbital regression of 3.70 mm was achieved.
Significant visual acuity improvement occurred in eyes with optic nerve compression.
Transient diplopia resolved within 8 weeks; one case of frontal sinus obstruction responded to medical therapy.

Conclusions:

Endonasal endoscopic orbital decompression is an effective, safe, and minimally invasive treatment for Graves orbitopathy.
The procedure successfully addresses proptosis and visual loss.
No long-term diplopia issues were observed with this approach.