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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

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Related Experiment Video

Updated: May 10, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

[Diagnosis of multiple sclerosis].

Makoto Matsui1, Shigemi Nagayama

  • 1Department of Neurology, Kanazawa Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 20, 2013
PubMed
Summary

The prevalence of multiple sclerosis (MS) in Japan is rising, necessitating early diagnosis. Revised McDonald criteria aid in identifying MS through magnetic resonance imaging (MRI) and clinical findings.

Area of Science:

  • Neurology
  • Clinical Diagnosis

Context:

  • Increasing prevalence of multiple sclerosis (MS) in Japan.
  • Need for early and accurate MS diagnosis by general physicians.

Purpose:

  • To highlight the utility of the 2010 McDonald criteria revisions for MS diagnosis.
  • To emphasize the importance of integrating MRI findings with clinical and laboratory data.

Summary:

  • The 2010 McDonald criteria simplify magnetic resonance imaging (MRI) analysis for dissemination in space (DIS) and dissemination in time (DIT).
  • Accurate MS diagnosis requires consideration of patient history, neurological examination, cerebrospinal fluid analysis, and electrophysiological tests.
  • Refined diagnostic criteria are needed for earlier patient recruitment into disease-modifying therapies.

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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

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Last Updated: May 10, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Impact:

  • Improved diagnostic accuracy for multiple sclerosis in Japan.
  • Facilitation of earlier treatment initiation for MS patients.
  • Potential for better long-term prognosis through timely intervention.