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Updated: May 10, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
[Diagnosis of multiple sclerosis]
Makoto Matsui1, Shigemi Nagayama
1Department of Neurology, Kanazawa Medical University.
Abstract:
The prevalence of multiple sclerosis (MS) in Japan has been increasing in recent years, and general physicians should be alert for early and correct diagnosis of this disorder. For this purpose, the 2010 revisions to the McDonald criteria are helpful, as they employed simplified parameters for magnetic resonance imaging (MRI) findings to confirm dissemination in space (DIS) as well as dissemination in time (DIT). However, physicians must also carefully consider medical history, combinations of neurological symptoms and signs, and findings obtained from cerebrospinal fluid samples and/or electrophysiological tests for individual diagnoses. Thus, establishment of more specific and sensitive criteria in the near future will help to recruit very early MS patients for disease-modifying therapies, leading to better prognosis.
Insights
The prevalence of multiple sclerosis (MS) in Japan is rising, necessitating early diagnosis. Revised McDonald criteria aid in identifying MS through magnetic resonance imaging (MRI) and clinical findings.
Area of Science:
- Neurology
- Clinical Diagnosis
Context:
- Increasing prevalence of multiple sclerosis (MS) in Japan.
- Need for early and accurate MS diagnosis by general physicians.
Purpose:
- To highlight the utility of the 2010 McDonald criteria revisions for MS diagnosis.
- To emphasize the importance of integrating MRI findings with clinical and laboratory data.
Summary:
- The 2010 McDonald criteria simplify magnetic resonance imaging (MRI) analysis for dissemination in space (DIS) and dissemination in time (DIT).
- Accurate MS diagnosis requires consideration of patient history, neurological examination, cerebrospinal fluid analysis, and electrophysiological tests.
- Refined diagnostic criteria are needed for earlier patient recruitment into disease-modifying therapies.
Impact:
- Improved diagnostic accuracy for multiple sclerosis in Japan.
- Facilitation of earlier treatment initiation for MS patients.
- Potential for better long-term prognosis through timely intervention.
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