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Updated: May 10, 2026

Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells
Published on: March 8, 2024
[Current situation and future prospect of cytoglobin research]
1Department of Hepatology, Graduate School of Medicine, Osaka City University.
Abstract:
Cytoglobin was originally discovered from cultured rat hepatic stellate cells by using proteomics analysis in our laboratory in 2001. Cytoglobin is a hexacoordinate globin that is different from the traditional pentacoordinate globins like myoglobin and hemoglobin. Human cytoglobin has about 25% amino acid identity with vertebrate myoglobin and hemoglobin, and 16% with human neuroglobin that is another type of globin present specifically in the nervous system. Besides its function as O2, carbon monoxide, and nitric oxide-binding molecule, cytoglobin exhibits antioxidative properties under hypoxic condition. Recent analyses using clinical samples have indicated that cytoglobin may be a tumor suppressor gene because cytoglobin mRNA expression in cancer tissues is down-regulated through hypermethylation of cytoglobin gene promoter. In this review, the history of cytoglobin research, its current status and future prospects will be discussed.
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