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Leptin levels in patients with psoriasis: a meta-analysis
1Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China. zhukunju1111@163.com
Clinical and Experimental Dermatology
|June 20, 2013
Summary
Leptin levels are elevated in individuals with psoriasis compared to healthy controls. This meta-analysis confirms higher leptin in psoriasis patients, particularly in serum samples.
Area of Science:
- Dermatology
- Endocrinology
- Metabolic Research
Background:
- Inconsistent findings exist regarding leptin levels in psoriasis patients.
- Leptin, a key adipokine, plays a role in inflammation and metabolism.
Purpose of the Study:
- To conduct a meta-analysis evaluating leptin levels in psoriasis.
- Compare leptin levels between psoriasis patients and healthy controls.
Main Methods:
- Systematic literature search of PubMed, EMBASE, and Cochrane Library.
- Pooled weighted mean differences (WMDs) calculated using random-effects and fixed-effects models.
- Heterogeneity assessed using Cochran Q and I(2) statistics.
Main Results:
- 11 studies (773 patients, 570 controls) included.
- Significantly higher leptin levels in psoriasis patients (WMD = 7.24, 95% CI 4.55-9.93).
- Elevated leptin observed in serum samples, but not plasma samples.
Conclusions:
- Leptin levels are demonstrably higher in psoriasis patients.
- Further research is needed to understand leptin's role in psoriasis pathogenesis.