Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

APOE*4 risk-modifying genes and drug targets in Alzheimer's disease through cell-type-specific genomic analyses.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

An <i>APOE</i> *4-Informed Genomic Atlas of the X Chromosome in Alzheimer's Disease.

medRxiv : the preprint server for health sciences·2026
Same author

Proteomic Signatures of Protected <i>APOE</i>-ε4 Carriers Reveal Causal Pathways Associated with Delayed Alzheimer's Disease Onset.

medRxiv : the preprint server for health sciences·2026
Same author

Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Population-scale burden analysis of rare damaging coding variants identifies novel risk genes for Alzheimer's disease and Parkinson's disease.

medRxiv : the preprint server for health sciences·2026
Same author

Plasma neurofilament light is associated with hippocampal volume and memory performance but not functional connectivity in older adults with and without mild cognitive decline.

Aging brain·2026

Related Experiment Video

Updated: May 10, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Disordered reward processing and functional connectivity in trichotillomania: a pilot study.

Matthew P White1, William R Shirer, Maria J Molfino

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University Medical Center, 401 Quarry Road, Stanford, CA 94305, USA. mpwhite@stanford.edu

Journal of Psychiatric Research
|June 20, 2013
PubMed
Summary
This summary is machine-generated.

This study found that individuals with Trichotillomania (TTM) exhibit altered reward processing, specifically in the nucleus accumbens, and reduced connectivity in key brain regions. These findings suggest reward system dysfunction in TTM pathophysiology.

Keywords:
AddictionImpulse control disorderOCDRewardTrichotillomaniafMRI

More Related Videos

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Related Experiment Videos

Last Updated: May 10, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • The neurobiology of Trichotillomania (TTM) is not well understood.
  • Emerging evidence suggests TTM may involve altered reward processing.
  • This study is the first to explore reward processing in TTM using fMRI.

Purpose of the Study:

  • To investigate differences in reward processing between TTM and healthy controls (HC).
  • To utilize both event-related and resting-state fMRI.
  • To employ two complementary resting-state analysis methods.

Main Methods:

  • 21 unmedicated TTM subjects and 14 HC subjects underwent resting-state fMRI.
  • A subset of participants (13 TTM, 12 HC) completed a monetary incentive delay (MID) task.
  • Analyses included functional connectivity to the nucleus accumbens and dual regression within a reward network.

Main Results:

  • TTM subjects showed decreased nucleus accumbens (NAcc) activation during reward anticipation.
  • TTM subjects exhibited NAcc over-activity to both gains and losses.
  • Resting-state analyses revealed decreased dorsal anterior cingulate (dACC) and basolateral amygdala connectivity in TTM.

Conclusions:

  • Disordered reward processing in the NAcc may contribute to TTM.
  • Reduced modulatory input from the dACC and basolateral amygdala is implicated.
  • These findings offer insights into the pathophysiology of TTM.