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Related Experiment Video

Updated: May 10, 2026

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Neonatal congenital heart block.

Ayse Yildirim¹, F Sedef Tunaoolu, Aysu Turkmen Karaaoac

¹Departments of Pediatric cardiology, Pediatrician Kartal Kobuyolu Training and Research Heart Hospital, Itanbul, Turkey. ayildirimmd@yahoo.com

Indian Pediatrics

|June 20, 2013

Summary

Congenital heart block (CHB) is linked to maternal autoantibodies, causing fetal heart conduction issues. Early echocardiographic surveillance and intrauterine treatments are crucial for managing this neonatal lupus complication.

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Implantation of Total Artificial Heart in Congenital Heart Disease

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

Area of Science:

Immunology
Cardiology
Obstetrics

Background:

Congenital Heart Block (CHB) is a severe complication of neonatal lupus erythematosus.
Maternal anti-SSA/Ro or anti-SSB/La antibodies crossing the placenta around 12 weeks gestation cause CHB.
This leads to fetal heart conduction system inflammation, fibrosis, and scarring in the second trimester.

Purpose of the Study:

To highlight the association between maternal autoantibodies and CHB.
To emphasize the importance of early fetal echocardiographic surveillance.
To review intrauterine treatment options for CHB.

Main Methods:

Review of literature on CHB pathogenesis and management.
Fetal echocardiography for surveillance.
Intrauterine interventions including medications and pacing.

Main Results:

CHB diagnosis typically occurs between 18-24 weeks gestation.
First and second-degree atrioventricular (AV) blocks can vary, but third-degree AV block is irreversible.
Various intrauterine treatments show controversial efficacy.

Conclusions:

Maternal autoantibody-positive mothers require close fetal echocardiographic surveillance from the early second trimester.
Intrauterine treatments for CHB, though debated, include medications and pacing.
Aggressive medical treatment combined with pacing is used for non-responsive infants.