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The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
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[The EXIT procedure].

S Lehmann1, A Blödow, W Flügel

  • 1Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie und Kommunikationsstörungen, HELIOS Hörzentrum Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Berlin-Buch, Deutschland. sina.lehmann@helios-kliniken.de

HNO
|June 20, 2013
PubMed
Summary
This summary is machine-generated.

The ex utero intrapartum treatment (EXIT) procedure successfully managed a fetus with a large cervical teratoma causing airway obstruction. This intervention ensured fetal airway protection during a complex delivery, highlighting its critical role in similar high-risk obstetric cases.

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Area of Science:

  • Obstetrics and Gynecology
  • Fetal Surgery
  • Neonatal Care

Background:

  • The ex utero intrapartum treatment (EXIT) procedure is a specialized intervention for fetuses facing predictable postpartum airway obstruction.
  • Indications include fetal neck tumors, tracheal obstruction, diaphragmatic hiatus hernia, and congenital high airway obstruction syndrome (CHAOS).
  • Large cervical tumors pose delivery challenges due to head reclination and potential airway compromise.

Observation:

  • A case involving an unborn fetus with a large cervical teratoma was monitored throughout pregnancy using ultrasound and MRI.
  • The teratoma was identified as a significant risk for cervical airway obstruction.
  • The EXIT procedure was deemed necessary due to the predicted delivery complications.

Findings:

  • The EXIT procedure was successfully performed on the fetus with a large cervical teratoma.
  • Continuous fetal airway protection was maintained during the procedure.
  • The interdisciplinary approach to the EXIT procedure was crucial for its successful execution.

Implications:

  • The successful EXIT procedure demonstrates its efficacy in managing complex fetal airway obstructions caused by cervical teratomas.
  • This case underscores the importance of advanced imaging and multidisciplinary collaboration in high-risk fetal surgeries.
  • The EXIT procedure offers a viable solution for complex deliveries, ensuring fetal survival and minimizing neonatal complications.