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Maxam-Gilbert Sequencing

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...

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Related Experiment Video

Updated: May 10, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

Excimer formation by stacking G-quadruplex blocks

Nguyen Thuan Dao¹, Reinhard Haselsberger, Maria-Elisabeth Michel-Beyerle

¹School of Physical and Mathematical Science, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry

|June 20, 2013

Summary

No abstract available in PubMed .

Keywords:

DNA NMR spectroscopy excimers fluorescence π stacking

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