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Updated: May 10, 2026
07:51
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Behçet's disease and pregnancy.
Nicolas Noel1, Bertrand Wechsler, Jacky Nizard
1Groupe Hospitalier Pitié-Salpêtrière, AP-HP, and Université Pierre et Marie Curie, Paris VI, Paris, France.
Arthritis and Rheumatism
|June 20, 2013
Summary
Behçet's disease (BD) flares are less common during pregnancy, especially when treated with colchicine. Pregnancy in women with BD does not increase the risk of pregnancy complications, with no impact on neonatal outcomes.
Area of Science:
- Rheumatology
- Obstetrics and Gynecology
- Immunology
Background:
- Behçet's disease (BD) is a multisystemic inflammatory disorder.
- The impact of pregnancy on BD disease activity and pregnancy outcomes requires further investigation.
Purpose of the Study:
- To investigate the interplay between Behçet's disease and pregnancy.
- To assess BD flare incidence during pregnancy compared to non-pregnant periods.
- To identify factors associated with pregnancy complications in BD patients.
Main Methods:
- Retrospective study of 76 pregnancies in 46 patients with BD.
- Patients served as their own historical controls to compare BD flare rates.
- Analysis of factors influencing pregnancy complications.
Main Results:
- BD flares occurred less frequently during pregnancy (35.5%) compared to non-obstetric periods.
- Oral/genital ulcerations and ocular complications were most common during flares.
- Pregnancy complications occurred in 15.8% of pregnancies; deep vein thrombosis history increased obstetric complication risk.
- Colchicine treatment showed a trend towards lower flare rates.
- BD did not affect gestational age at delivery or neonatal outcomes.
Conclusions:
- Behçet's disease activity may decrease during pregnancy, particularly with colchicine treatment.
- Pregnancy in women with BD is not associated with an increased risk of pregnancy-related complications.
- Neonatal outcomes are not adversely affected by BD.
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