Related Experiment Videos
Antituberculosis therapy-associated cutaneous leukocytoclastic vasculitis
Vidyut Bhatia1, Anupam Sibal, Shilpy Rajgarhia
1Apollo Center for Advanced Pediatrics, Indraprastha Apollo Hospital, New Delhi 110076, India.
Journal of Tropical Pediatrics
|June 20, 2013
Summary
Rifampicin and pyrazinamide, used for tuberculosis treatment, can rarely cause cutaneous leukocytoclastic vasculitis (CLV). This drug-induced vasculitis presented as purpuric lesions and resolved after medication withdrawal and corticosteroid therapy.
Area of Science:
- Dermatology
- Rheumatology
- Infectious Diseases
Background:
- Antituberculosis therapy is crucial for managing tuberculosis.
- Cutaneous leukocytoclastic vasculitis (CLV) is an uncommon adverse drug reaction.
- Rifampicin and pyrazinamide are first-line antituberculosis drugs.
Observation:
- A 14-year-old male with disseminated tuberculosis developed purpuric skin lesions.
- Lesions appeared 1.5 months into antituberculosis treatment.
- Histopathology confirmed leukocytoclastic vasculitis.
Findings:
- The patient's CLV was attributed to rifampicin and pyrazinamide.
- Discontinuation of these drugs led to improvement of skin lesions.
- Corticosteroid treatment further aided in resolving the vasculitis.
Implications:
- This case highlights a rare adverse drug reaction to common antituberculosis medications.
- Clinicians should consider drug-induced CLV in patients on antituberculosis therapy presenting with purpuric lesions.
- Prompt recognition and management, including drug cessation, are essential for favorable outcomes.
Related Concept Videos
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
01:26Pulmonary Tuberculosis IV
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...