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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

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Motor abnormalities as a putative endophenotype for Autism Spectrum Disorders.

Gianluca Esposito¹, Sergiu P Paşca

¹RIKEN Brain Science Institute, Unit for Affiliative Social Behavior Wako-Shi, Saitama, Japan.

Frontiers in Integrative Neuroscience

|June 20, 2013

Summary

Motor abnormalities in Autism Spectrum Disorders (ASDs) may serve as early indicators, independent of social or language development. Stratifying ASDs by motor development could improve prediction and treatment.

Keywords:

Autism Spectrum Disorders early assessment early screening endophenotype motor abnormalities

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Area of Science:

Neuroscience
Developmental Psychology
Genetics

Background:

Autism Spectrum Disorders (ASDs) are complex behavioral conditions with core social communication deficits and repetitive behaviors.
Neuropathological studies have not yet identified definitive cellular markers for ASDs, creating a gap between clinical presentation and neurobiology.
Motor abnormalities are frequently observed in ASDs, despite not being core diagnostic criteria.

Purpose of the Study:

To review evidence supporting motor abnormalities as a potential endophenotype for ASDs.
To explore the utility of motor development as an early indicator for ASDs.
To propose the use of motor development stratification for improved outcome prediction, targeted treatments, and understanding neurobiological mechanisms in ASDs.

Main Methods:

This is a perspective article, synthesizing existing research and evidence.
It involves a review of literature on motor abnormalities in Autism Spectrum Disorders.
The authors present arguments and propose a framework based on current findings.

Main Results:

Motor abnormalities are consistently reported across the spectrum of Autism Spectrum Disorders.
These motor deficits may be independent of social and linguistic development, suggesting potential as early indicators.
Stratification by motor development could enhance outcome prediction and treatment specificity.

Conclusions:

Motor abnormalities represent a promising endophenotype for Autism Spectrum Disorders.
Early identification of motor deficits may facilitate earlier diagnosis and intervention.
Analyzing motor development can potentially reveal underlying neurobiological mechanisms and inform personalized medicine approaches for ASDs.