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Updated: May 10, 2026

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research
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Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

Detecting circulating tumor cells: current challenges and new trends.

Bin Hong1, Youli Zu

  • 1TeloVISION, LLC, 1281 Win Hentschel Blvd. West Lafayette, IN 47906, USA.

Theranostics
|June 20, 2013
PubMed
Summary

Circulating tumor cells (CTCs) are key to cancer metastasis. This review discusses current CTC detection methods, their limitations, and emerging technologies for improved cancer diagnosis and treatment monitoring.

Keywords:
CTC: Circulating tumor cellCTDNA: Circulating tumor DNACTM: Circulating tumor microemboliCTMat: Circulating tumor materialsPOCT: Point-of-care test.

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Capture and Release of Viable Circulating Tumor Cells from Blood

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Capture and Release of Viable Circulating Tumor Cells from Blood
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Capture and Release of Viable Circulating Tumor Cells from Blood

Published on: October 28, 2016

Area of Science:

  • Oncology
  • Biomarker Discovery
  • Molecular Diagnostics

Background:

  • Circulating tumor cells (CTCs) are crucial for cancer metastasis and have potential as biomarkers for early detection, diagnosis, prognosis, and treatment response.
  • Current CTC detection assays face methodological constraints, limiting their clinical utility.
  • Understanding CTC biology and detection technologies is vital for advancing cancer care.

Purpose of the Study:

  • To comprehensively review and discuss the advantages and disadvantages of existing CTC detection assays.
  • To evaluate novel targets for CTC detection, including tumor microemboli, cell fragments, and circulating DNA.
  • To assess emerging approaches for CTC detection, such as telomerase-based, aptamer-based assays, and cell functional analysis.

Main Methods:

  • Literature review of reported CTC assays.
  • Analysis of pros and cons of current CTC detection methodologies.
  • Evaluation of novel CTC detection targets and emerging technologies.

Main Results:

  • Current CTC assays have significant limitations hindering widespread clinical application.
  • Tumor cell-derived materials like microemboli, fragments, and DNA show promise as alternative detection targets.
  • Emerging technologies offer potential for more sensitive and specific CTC detection.

Conclusions:

  • A critical assessment of current CTC detection methods reveals a need for improved assay systems.
  • Exploring novel targets and advanced technologies is essential for enhancing the clinical utility of CTC detection.
  • This review aims to guide the scientific community in developing more efficient CTC assay systems for improved cancer management.