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Related Experiment Video

Updated: May 10, 2026

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Published on: August 28, 2013

Prostatic stromal hyperplasia with atypia.

Ryan C Hutchinson¹, Kevin J Wu, John C Cheville

¹Department of Urology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Case Reports in Urology

|June 20, 2013

Summary

Prostatic stromal hyperplasia with atypia (PSHA) is a rare prostate finding that can mimic sarcoma but has an indolent clinical course. This study reviews a case and literature on this uncommon histologic diagnosis.

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Last Updated: May 10, 2026

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

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Published on: August 28, 2013

Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells

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Published on: June 22, 2013

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization

Published on: November 17, 2023

Area of Science:

Uropathology
Surgical Pathology
Oncology

Background:

Prostatic stromal hyperplasia with atypia (PSHA) is an uncommon incidental finding in prostate tissue.
Its bizarre histologic appearance can lead to misdiagnosis as sarcoma.
PSHA is characterized by an indolent clinical course without extraprostatic progression.

Purpose of the Study:

To present a case of PSHA discovered during prostate biopsy.
To review the existing literature on PSHA.
To clarify the diagnostic and prognostic implications of PSHA.

Main Methods:

Case report of PSHA identified on prostate biopsy.
Literature review of PSHA in PubMed and other databases.
Histologic analysis and clinical correlation.

Main Results:

The case presented showed PSHA on prostate biopsy, initially raising concern for malignancy.
Literature review confirmed PSHA as a rare entity with benign behavior.
No evidence of extraprostatic extension or aggressive clinical progression was noted in reviewed cases.

Conclusions:

PSHA is a rare but distinct histologic finding in prostate pathology.
Despite concerning morphology, PSHA follows an indolent clinical course.
Accurate diagnosis of PSHA is crucial to avoid unnecessary aggressive treatment.