Related Experiment Video
Updated: May 10, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
First-order derivative spectrophotometric estimation of nabumetone and paracetamol in tablet dosage form
Ambadas R Rote1, Swapnil R Bhalerao
1Department of Pharmaceutical Chemistry, MGV's Pharmacy College, Pune University, Panchavati, Nashik, India.
Aim:
To develop and validate a simple, precise and accurate spectrophotometric method for the simultaneous estimation of nabumetone and paracetamol in their combined tablet dosage form. This method is based on first-order derivative spectroscopy.
Materials And Methods:
For determination of sampling wavelengths, each of nabumetone and paracetamol were scanned in the wavelength range of 200-400 nm in the spectrum mode and sampling wavelengths were selected at 261 nm (zero crossing of nabumetone) where paracetamol showed considerable absorbance and at 248.2 nm (zero crossing of paracetamol) where nabumetone showed considerable absorbance.
Results:
Beer's law obeyed in the concentration range of 3-18 μg/ml for both the drugs. The correlation coefficients were found to be 0.9992 and 0.9998 for nabumetone and paracetamol, respectively. Mean recoveries were found satisfactory.
Conclusion:
The proposed method can be successfully applied for simultaneous estimation of nabumetone and paracetomol.
More Related Videos
09:24Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
10:17High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Related Concept Videos
Dosage Regimen Designs: Nomograms and Tabulations
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Dosage Regimens: Partial Pharmacokinetic Parameters
Measurement of Bioavailability: Pharmacodynamic Methods
Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters
One key aspect of the noncompartmental approach is determining a drug's total clearance. This can be done by dividing the drug dose by the area under the concentration-time curve from zero to infinity. The area under the concentration-time curve represents the drug's overall...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations