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Updated: May 10, 2026
Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer
1Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea. bitsugar@catholic.ac.kr
Purpose:
The aim of this study was to establish the guidelines for detecting early recurrences of advanced epithelial ovarian cancer by use of the CA-125 level.
Materials And Methods:
Eighty-five of the patients who met the inclusion criteria were enrolled in this study. The authors examined 25 incremental changes of CA125 from one to 25 IU/ml, and compared the CA-125 value with other prognostic factors. Increases in the CA-125 level from the nadir level were expressed as CA-125- increments.
Results:
Among the 25 increments, a CA-125-8 (eight IU/ml) was selected as the predictor that was the most efficient and time-effective. CA-125-8 had a sensitivity of 91.5%, a specificity of 84.6%, a positive predictive value of 93.1%, a negative predictive value of 81.5%, an efficiency of 89.4%. and a median lead-time of 68.5 days (p <0.0001).
Conclusion:
The authors suggest the incremented CA-125-8 as a predictor of recurrent advanced ovarian cancer.
