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Updated: May 10, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

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Published on: June 16, 2020

Squamous cell carcinoma lung with progressive systemic sclerosis.

Susmita Kundu1, Ritabrata Mitra, Swapnendu Misra

  • 1Dept. of Pulmonary Medicine, IPGMER and SSKM Hospital, Kolkata.

The Journal of the Association of Physicians of India
|June 21, 2013
PubMed
Summary
This summary is machine-generated.

Progressive systemic sclerosis (PSS) is rarely linked to lung cancer, most commonly bronchioloalveolar carcinoma. This case highlights squamous cell carcinoma in a non-smoker with PSS presenting with respiratory symptoms.

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Area of Science:

  • Pulmonology
  • Oncology
  • Rheumatology

Background:

  • Progressive systemic sclerosis (PSS) is an autoimmune disease with rare but recognized associations with lung malignancy.
  • Bronchioloalveolar carcinoma (BAC) is the most frequent lung cancer in PSS patients, followed by squamous cell carcinoma, oat cell carcinoma, and anaplastic carcinoma.

Observation:

  • A 55-year-old non-smoking male patient with PSS presented with worsening dyspnea and dry cough.
  • Initial clinical and radiological assessments suggested non-resolving pneumonia.

Findings:

  • Subsequent investigations confirmed a diagnosis of squamous cell carcinoma of the lung in the patient with PSS.
  • This case underscores the importance of considering lung malignancy in PSS patients presenting with respiratory symptoms.

Implications:

  • This case expands the understanding of lung cancer types associated with PSS beyond the most common BAC.
  • Highlights the diagnostic challenge, as initial presentation can mimic pneumonia.
  • Emphasizes the need for thorough investigation in PSS patients with unexplained respiratory decline.