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Updated: Aug 1, 2026

Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice
Published on: November 4, 2013
[Changes in skeletal muscles in death caused by hypothermia]
T Sigrist1, C Markwalder, R Dirnhofer
1Gerichtsmedizinisches Institut, Kantonsspital St. Gallen, Schweiz.
Abstract:
The review of 32 deaths resulting from hypothermia yielded mostly the common pathological findings as bright red livores, haemolytic frost marks of the skin and Wichnewski erosions of the gastric mucosa. In addition the muscle system of the body core (musc. ileopsoas) showed hemorrhages and histologically necrosis of its fibres in form of segmental and discoid sarcoplasmatic alteration. These changes are a quite specific sign of death due to hypothermia, as far as mechanical injury can be excluded. For best result however a special autopsy technique and an appropriate histological staining are advisable.
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