Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Decreased blood fluidity in progressive systemic scleroderma].

E Ernst1, E F Lohmaier, M Meurer

  • 1Abt. Physikalische Medizin und Rehabilitation, Medizinische Hochschule Hannover.

Zeitschrift Fur Rheumatologie
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The "Hoddle Muddle": using faith healers and other complementary therapists in sports medicine.

British journal of sports medicine·1998
Same author

Does post-exercise massage treatment reduce delayed onset muscle soreness? A systematic review.

British journal of sports medicine·1998
Same author

The rise and fall of complementary medicine.

Journal of the Royal Society of Medicine·1998
Same author

The prevalence of complementary/alternative medicine in cancer: a systematic review.

Cancer·1998
Same author

Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy.

BMJ (Clinical research ed.)·1998
Same author

[Phytotherapy. 1. Use in diseases of the locomotor system].

Fortschritte der Medizin·1998

Blood flow is significantly impaired in patients with progressive systemic sclerosis (PSS), with altered viscosity and red cell aggregation contributing to disease pathology. This loss of blood fluidity may play a role in Raynaud phenomena experienced by all patients.

Area of Science:

  • Rheology
  • Hematology
  • Systemic Sclerosis Pathophysiology

Context:

  • Progressive systemic sclerosis (PSS) is a complex autoimmune disease.
  • Understanding the rheological properties of blood is crucial for disease characterization.
  • Previous research has not fully elucidated blood flow abnormalities in PSS.

Purpose:

  • To define and characterize blood rheology in patients with progressive systemic sclerosis (PSS).
  • To investigate the relationship between rheological parameters and clinical manifestations in PSS.
  • To explore the potential role of altered blood fluidity in the pathogenesis of Raynaud phenomena in PSS.

Summary:

  • Blood and plasma viscosity, hematocrit, red cell aggregation, and deformability were measured in 55 PSS patients and controls.

Related Experiment Videos

  • Significant alterations in blood fluidity, including increased viscosity and impaired red cell aggregation/deformability, were observed in PSS patients, excluding hematocrit.
  • While medications showed no clear rheological impact, clinical status correlated with these changes, suggesting a pathophysiological link.

    • Impact:

    • The study identifies a significant loss of blood fluidity in PSS, contributing to disease understanding.
    • Findings suggest that impaired blood rheology may be a key factor in the development of Raynaud phenomena in PSS patients.
    • This research provides a basis for exploring therapeutic strategies targeting blood rheology in PSS management.