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Restoring hemostasis: fibrinogen concentrate versus cryoprecipitate
Brian M Elliott1, Louis M Aledort
1Division of Hematology/Oncology, Mount Sinai Medical Center, One Gustave L Levy Place, Box 1079, NY 10029, USA. brianemd@gmail.com
Expert Review of Hematology
|June 21, 2013
Summary
Maintaining adequate fibrinogen is crucial for hemostasis in acquired hypofibrinogenemia. This review compares cryoprecipitate and fibrinogen concentrate for effective treatment and reduced transfusions.
Area of Science:
- Coagulation Science
- Hematology
- Transfusion Medicine
Background:
- Fibrinogen is vital for hemostasis.
- Acquired hypofibrinogenemia necessitates adequate fibrinogen levels.
- Uncontrolled bleeding requires prompt management.
Purpose of the Study:
- To review the hemostatic process and coagulopathy assessment.
- To discuss the efficacy and safety of cryoprecipitate and fibrinogen concentrate.
- To examine clinical use, product variations, preparation, and cost.
Main Methods:
- Literature review of hemostatic process.
- Review of coagulopathy assessment methods.
- Comparative analysis of cryoprecipitate and fibrinogen concentrate.
Main Results:
- Cryoprecipitate and fibrinogen concentrate are options for acquired hypofibrinogenemia.
- Both agents aim to restore fibrinogen levels and achieve hemostasis.
- Efficacy, safety, and transfusion reduction are key considerations.
Conclusions:
- Adequate fibrinogen is essential for patients with acquired hypofibrinogenemia.
- Cryoprecipitate and fibrinogen concentrate offer therapeutic options.
- Clinical use involves product composition, preparation time, and cost analysis.
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