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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
Published on: October 14, 2025
Inflammatory bowel disease: etiology, pathogenesis and current therapy.
1Centre for Cancer and Inflammation Research, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong SAR, China. jksko@hkbu.edu.hk.
Current Pharmaceutical Design
|June 21, 2013
Summary
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, lacks a cure. This review details current treatments and investigational therapies aimed at reducing gut inflammation and promoting healing.
Area of Science:
- Gastroenterology
- Immunology
- Pharmacology
Background:
- Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is characterized by idiopathic gut inflammation.
- Etiology involves complex interactions of environmental, genetic, and immune factors, with no definitive cure currently available.
Purpose of the Study:
- To review the pathophysiology of IBD.
- To summarize current and emerging therapeutic strategies for managing IBD.
Main Methods:
- Comprehensive literature review of IBD pathophysiology and treatment modalities.
- Analysis of pharmacotherapy, including corticosteroids, aminosalicylates, immunomodulators, and novel agents.
- Inclusion of investigational therapies such as anti-TNF agents, gene therapy, dietary interventions, and compounds from tobacco smoke and herbal medicines.
Main Results:
- Current treatments focus on down-regulating excessive immune responses to promote mucosal healing.
- Pharmacotherapies modulate key inflammatory mediators like cytokines and reactive metabolites.
- Investigational agents show promise for more targeted and effective IBD management.
Conclusions:
- Achieving a curative outcome for IBD requires further development of novel, target-oriented therapies.
- Additional experimental and clinical studies are essential to validate the efficacy and safety of emerging treatments.
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