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Related Experiment Video

Updated: May 10, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
08:04

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

[The spleen in experimental surgery].

István Furka1, Norbert Németh, Irén Mikó

  • 1Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Sebészeti Intézet, Sebészeti Műtéttani Tanszék. 4032 Debrecen, Nagyerdei krt. 98. ifurka@med.unideb.hu

Magyar Sebeszet
|June 21, 2013
PubMed
Summary

Spleen autotransplantation using spleen chips can restore partial splenic function after injury. This technique helps prevent overwhelming post-splenectomy infection and disseminated intravascular coagulation (DIC).

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Area of Science:

  • Surgical innovation in organ preservation and transplantation.
  • Regenerative medicine and tissue engineering.
  • Immunology and hematology.

Context:

  • The spleen, when injured but functionally intact, can be preserved using surgical methods.
  • Two novel techniques developed include partial spleen resection and spleen autotransplantation ('spleen-apron' technique).
  • Extensive follow-up investigations have been conducted over three decades.

Purpose:

  • To evaluate the viability and efficacy of spleen autotransplantation.
  • To investigate the functional and structural recovery of the spleen post-transplantation.
  • To explore the role of hemopoietic stem cells in spleen regeneration.

Summary:

  • Spleen autotransplantation involves implanting spleen chips into the greater omentum.

Related Experiment Videos

Last Updated: May 10, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
08:04

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

  • Post-surgical investigations include comprehensive laboratory tests, advanced imaging (SPECT, NanoSPECT/CT), and morphological analysis.
  • Implanted spleen chips demonstrate partial restoration of splenic functions through remodelling and neovascularisation.

    • Impact:

    • Confirms the viability of spleen autotransplantation as a method to save injured spleens.
    • Highlights the potential for restoring splenic functions, crucial for preventing post-splenectomy complications.
    • Provides evidence for the effectiveness of the 'spleen-apron' technique in animal models.