[Hemorheological investigations in experimental surgery]

Area of Science:

• Hemodynamics and microcirculation research.
• Physiology of blood flow and tissue perfusion.

Context:

• Hemorheological parameters (blood viscosity, hematocrit, red blood cell deformability/aggregation) are vital for tissue perfusion.
• Altered hemorheology affects endothelial function and slows microcirculation, impairing capillary perfusion.

Purpose:

• To explore the impact of altered hemorheological status on tissue perfusion and microcirculation.
• To understand pathophysiological processes in experimental surgery-induced ischemia-reperfusion.
• To identify challenges in experimental surgery, including measurement comparability and interspecies differences.

Summary:

• Experimental surgery involving vascular clamping/release induces ischemia-reperfusion, altering red blood cells via changes in pH, free radicals, osmolarity, lactate, NO, and mechanical trauma.
• Impaired red blood cell deformability and aggregation significantly disturb microcirculation and capillary perfusion.
• Understanding these reversible/irreversible changes aids in identifying causes of perfusion issues and developing therapies.

Impact:

• Provides insights into the mechanisms underlying impaired tissue perfusion and microcirculation.
• Highlights the importance of considering hemorheological factors in surgical research.
• Aims to improve the relevance of experimental animal models for clinical applications.