Related Experiment Video

Updated: May 10, 2026

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice
11:24

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Published on: February 10, 2018

More benign lymphoproliferative disease after liver transplant in infants

Hossein Khedmat1, Mohammad Ebrahim Ghamar-Chehreh, Mohsen Amini

  • 1Baqiyatallah University of Medical Sciences, Tehran, Iran.

Progress in Transplantation (Aliso Viejo, Calif.)
|June 21, 2013
PubMed

Insights

Posttransplant lymphoproliferative disorders (PTLD) in infants after liver transplants are more often polymorphic and have a better outcome compared to older patients. Further research is needed.

Area of Science:

  • Pediatric Gastroenterology and Hepatology
  • Transplant Immunology
  • Oncology

Background:

  • Liver transplantation is common in infants, yet data on posttransplant lymphoproliferative disorders (PTLD) are scarce.
  • PTLD presents unique challenges in pediatric recipients.

Purpose of the Study:

  • To investigate the specific characteristics and clinical behavior of PTLD in infant liver transplant recipients.
  • To compare PTLD in infants with that in older pediatric and adult liver transplant recipients.

Main Methods:

  • A systematic literature review was performed using PubMed and Google Scholar.
  • Data from 205 PTLD cases across 24 reports were analyzed, focusing on 100 infant recipients (<2 years old at transplant).
  • Infant PTLD cases were compared with those in older children and adults.

Main Results:

  • PTLD lesions in infants were more frequently polymorphic compared to monomorphic lesions in older patients (P = .05).
  • Remission rates, metastasis frequency, and organ involvement showed no significant differences between age groups.
  • Infant liver transplant recipients with PTLD demonstrated a significantly better survival outcome (P = .05).

Conclusions:

  • PTLD in infant liver transplant recipients appears to be more benign with a favorable prognosis.
  • A prospective, multicenter research approach is recommended for further investigation.

More Related Videos

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...