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Updated: May 10, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Therapeutic options for a rising PSA after radical prostatectomy
Bradley C Carthon1, David M Marcus, Lindsey A Herrel
1Department of Hematology/Oncology, Emory University, Atlanta, GA 30322, USA.
Men experiencing biochemical recurrence (BCR) after prostate cancer surgery have multiple treatment options. Radiotherapy and systemic therapies can improve outcomes and survival for recurrent or metastatic prostate cancer.
Area of Science:
- Urology
- Oncology
- Medical treatment
Background:
- Radical prostatectomy is a primary treatment for localized prostate cancer.
- Biochemical recurrence (BCR) occurs in a significant proportion of patients post-surgery.
- Effective management strategies for BCR are crucial.
Purpose of the Study:
- To review current treatment algorithms for prostate cancer patients with BCR post-surgery.
- To detail existing and promising future therapies for BCR.
- To provide data on the efficacy of various treatment modalities.
Main Methods:
- Literature review of high-impact articles.
- Focus on randomized controlled trials and multi-institutional retrospective studies.
- Analysis of treatment options for BCR after prostatectomy.
Main Results:
- Differentiating local vs. distant failure guides treatment decisions.
- Adjuvant or salvage radiotherapy improves local control and overall survival.
- Systemic therapies offer survival advantages and symptom control for metastatic or castration-resistant prostate cancer (CRPC).
Conclusions:
- Multiple effective treatment options exist for BCR.
- Radiotherapy and systemic therapies play key roles in managing recurrent and metastatic prostate cancer.
- Current data support various therapies for rising PSA after surgery.
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