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Related Experiment Video

Updated: May 10, 2026

Multimedia Battery for Assessment of Cognitive and Basic Skills in Mathematics (BM-PROMA)

Multimedia Battery for Assessment of Cognitive and Basic Skills in Mathematics (BM-PROMA)

Published on: August 28, 2021

Developmental dyscalculia: a dysconnection syndrome?

Karin Kucian¹, Simone Schwizer Ashkenazi, Jürgen Hänggi

¹Center for MR-Research, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland, karin.kucian@kispi.uzh.ch.

Brain Structure & Function

|June 21, 2013

Summary

Children with developmental dyscalculia (DD) show reduced white matter integrity in the superior longitudinal fasciculus. This suggests DD may stem from impaired brain connections, impacting numerical understanding.

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Area of Science:

Neuroscience
Developmental Psychology
Cognitive Science

Background:

Numerical understanding is crucial for daily life.
Developmental dyscalculia (DD) involves significant challenges with numbers and magnitudes.
These difficulties are hypothesized to originate from neural impairments in key numerical processing regions.

Purpose of the Study:

To investigate white matter fiber integrity differences in children with DD compared to controls.
To utilize diffusion tensor imaging (DTI) to assess neural underpinnings of DD.
To explore the relationship between white matter integrity and numerical deficits.

Main Methods:

Diffusion tensor imaging (DTI) was employed to evaluate white matter integrity.
Behavioral measures related to numerical understanding were assessed.
A cohort of 15 children with DD (around 10 years old) and 15 matched controls participated.

Main Results:

A whole-brain comparison revealed significantly reduced fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) in children with DD.
Region of interest analysis highlighted deficits in SLF fibers near the intraparietal sulcus, a critical area for number processing.
These findings indicate deficient white matter tracts connecting parietal, temporal, and frontal regions in children with DD.

Conclusions:

The results suggest that developmental dyscalculia may be characterized by a 'dysconnection syndrome' due to impaired fiber projections.
The superior longitudinal fasciculus plays a vital role in integrating distributed brain processes.
These findings underscore the importance of considering domain-general connectivity mechanisms in the diagnosis and treatment of dyscalculia.