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Circulating chemerin decreases in response to a combined strength and endurance training

Tsvetan Stefanov1, Matthias Blüher, Anna Vekova

  • 1Medicobiological Unit, International Scientific Institute, National Sports Academy, Studentski Grad, 1700, Sofia, Bulgaria, tsvetan.stefanov@gmail.com.

Endocrine
|June 21, 2013
PubMed

Insights

Chemerin, linked to obesity and inflammation, was associated with cardiometabolic risks. A 6-month exercise program significantly reduced chemerin levels in overweight individuals, improving insulin resistance.

Area of Science:

  • Endocrinology and Metabolism
  • Exercise Physiology
  • Obesity Research

Background:

  • Chemerin, an adipokine, is implicated in obesity, inflammation, insulin resistance, and cardiovascular disease.
  • Understanding chemerin's role in cardiometabolic risk factors is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate the association between serum chemerin and cardiometabolic risk factors in a cross-sectional study.
  • To evaluate the effect of a 6-month combined exercise program on serum chemerin levels in overweight/obese, non-diabetic individuals.

Main Methods:

  • Cross-sectional analysis of 98 individuals assessing chemerin and various cardiometabolic parameters.
  • Intervention study with 79 sedentary, overweight/obese, non-diabetic participants in a 6-month combined exercise program (n=51) or control group (n=28).
  • Serum chemerin, lipids, glucose, insulin, HOMA-IR, blood pressure, hs-CRP, leucocytes, and leptin were measured.

Main Results:

  • Chemerin showed significant associations with total cholesterol, triglycerides, fasting insulin, HOMA-IR, systolic blood pressure, hs-CRP, leucocytes, and leptin, independent of age and BMI.
  • Chemerin was an independent determinant of HOMA-IR in multiple regression analysis.
  • The 6-month exercise program significantly reduced serum chemerin levels (p < 0.001) and improved HOMA-IR, with changes in chemerin correlating with HOMA-IR improvements.

Conclusions:

  • Serum chemerin is associated with multiple cardiometabolic risk factors in non-diabetic individuals, independent of BMI.
  • A 6-month combined exercise program effectively reduces circulating chemerin levels in overweight or obese individuals.
  • Exercise-induced reduction in chemerin may contribute to improved insulin sensitivity.

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